Vinashin Lines' new international standard liner Hoa Sen will start operating from northern Quang Ninh Province to southern Ho Chi Minh City in mid-December.
The ship, from Italy, can carry 1,000 passengers and 500 cars.
The 187-meter, seven-story Hoa Sen has luxurious cabins and modern conveniences, including a bar, karaoke, massage, fax and internet services.
The ship is designed to ride smoothly in all conditions, even during high winds common during the monsoon months.
The liner's 48-hour route will connect Hon Gai Port in Quang Ninh and Nha Rong Port in HCMC, with an eight-hour stop at Chan May Port in central Thua Thien Hue Province.
Vinashin plans to buy another liner from Italy to reduce the cruise time to 28 hours next year.